Birds of Indian Subcontinent

Pharmacokinetics of Doxycycline after Parenteral Administration in the Houbara Bustard (Chlamydotis undulata)

Publication Type:Journal Article
Year of Publication:1993
Authors:Greth, A, Gerlach, H, Gerbermann, H, Vassart, M, Richez, P
Journal:Avian Diseases
Date Published:1993
ISBN Number:00052086
Keywords:Chlamydotis, Chlamydotis macqueenii, Chlamydotis undulata, Neotis undulata, Otididae, Otis, Otis tarda
Abstract:Fourteen adult Houbara bustards (Chlamydotis undulata) infected with Chlamydia psittaci were administered doxycycline at 100 mg/kg body weight in seven intramuscular or subcutaneous injections at intervals of 7, 7, 7, 6, 6, and 5 days. Blood levels of doxycycline were measured after the first and seventh injections at the following intervals: 0, 12, 24, 36, 48, 72, 96, 120, 144, 168, and 180 hours. During these two periods, most of the birds showed plasma doxycycline levels in excess of 1 μg/ml, demonstrating effective doxycycline levels for 45 days. A multifactorial analysis of variance revealed no significant differences between males and females, between the two routes of administration, or among all four factors. /// Se trataron 14 aves avutardas hubara (Chlamydotis undulata) infectadas con Chlamydia psittaci, con doxiciclina a una dosis de 100 mg/kg de peso corporal, en siete inyeciones vía intramuscular o subcutánea a intervalos de 7, 7, 7, 6, 6 y 5 días. Los niveles de doxiciclina en la sangre fueron medidos después de la primera y la séptima inyección a los siguientes intervalos: 0, 12, 24, 36, 48, 72, 96, 120, 144, 168 y 180 horas. Durante estos dos períodos, la mayoría de las aves mostraron niveles de doxicilina mayores de 1 μg/ml, demostrando niveles efectivos de doxiciclina por 45 días. Un análisis multifactorial de varianza no reveló diferencias significantes entre hembras y machos, entre las dos rutas de administración ó entre todos los factores.
Short Title:Avian Diseases
Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith