AVIS-IBIS

Birds of Indian Subcontinent

Efficacy in Turkeys of Spray Vaccination with a Temperature-Sensitive Mutant of Bordetella avium (Art Vax™)

Publication Type:Journal Article
Year of Publication:1987
Authors:Houghten, GE, Skeeles, JK, Rosenstein, M, Beasley, JN, Slavik, MF
Journal:Avian Diseases
Volume:31
Issue:2
Date Published:1987
ISBN Number:00052086
Keywords:Meleagris, Meleagris gallopavo, Phasianidae
Abstract:Broad-breasted white turkeys were vaccinated with a temperature-sensitive mutant of Bordetella avium (Art Vax™) at 2 and 15 days of age and challenged at 22 days of age by contact with infected birds. Necropsy was performed at 35 days of age. Two vaccination protocols (eyedrop/oral and spray cabinet/spray bottle) and two challenge isolates (Arkansas 105 and North Carolina [NC] isolates) were used. Neither the spray nor the eyedrop/oral methods of vaccination prevented infection of the anterior trachea with either of the virulent challenge strains. The spray and eyedrop/oral methods of vaccination were equally effective in reducing the severity of gross lesions in the trachea. The vaccine reduced the severity of gross lesions in the tracheas of turkeys challenged with the NC isolate to a level approximately equal to that observed in unchallenged vaccinated controls, but the vaccine only moderately reduced the severity of lesions in birds challenged with the 105 isolate. /// Se vacunaron pavos blancos comerciales a los 2 y 15 días de edad con una cepa mutante de Bordetella avium sensible a la temperatura (Art Vax™) y se desafiaron a los 22 días mediante contacto con aves infectadas. A los 35 días se llevó a cabo la necropsia de los diferentes grupos. Se utilizaron 2 sistemas de vacunación (gota ocular/oral y gabinete de aspersión/botella aspersora) y 2 cepas de desafío (Arkansas 105 y Carolina del Norte). Ninguno de los métodos de vacunación previno la infección en el tercio anterior de la tráquea con cualquiera de las cepas de desafío. Tanto la vacunación por gota ocular/oral como por aspersión fueron igualmente efectivas para disminuir la severidad de las lesiones macroscópicas en la tráquea. La vacunación disminuyó la severidad de las lesiones producidas por la cepa de Carolina del Norte a un grado similar al observado en los controles vacunados no desafiados. Sin embargo, la vacunación sólo disminuyó moderadamente las lesiones producidas por la cepa Arkansas 105.
URL:http://www.jstor.org/stable/1590877
Short Title:Avian Diseases
Taxonomic name: 
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