| Publication Type: | Journal Article |
| Year of Publication: | 1987 |
| Authors: | Rhoades, KR, Rimler, RB |
| Journal: | Avian Diseases |
| Volume: | 31 |
| Issue: | 2 |
| Date Published: | 1987 |
| ISBN Number: | 00052086 |
| Keywords: | Meleagris, Meleagris gallopavo, Phasianidae |
| Abstract: | Intraperitoneal exposure of turkey poults to various concentrations of Bordetella avium sonicate containing heat-labile toxin indicated a high degree of toxicity: poults died after exposure to sonicate containing as little as 6.32 μg of protein. The toxic effects were dose-related: poults that received sonicate containing 158 μg of protein died in 4 to 6 1/2 hours, those that received 31.6 and 6.32 μg of protein died in 25 to 30 hours, and those that received 1.2 μg survived the 6-day course of the study and were apparently unaffected. Histologic examination of poults that received lethal doses of the toxin revealed degeneration and necrosis of parenchymal cells of the liver and pancreas as well as hyperemia, hemorrhage, and necrosis of the mucosa of the small intestine. No lesions were observed in poults that received the sublethal dose of toxin or in unexposed poults. Repeated intranasal exposure of poults to the sonicate did not produce clinical signs of disease or gross lesions. /// Se observó un alto grado de toxicidad luego de la inoculación intraperitoneal de pavos jóvenes con varias concentraciones sonicadas de Bordetella avium que contenían toxina sensible al calor. Los pavitos murieron luego de la inoculación de cantidades tan pequeñas como 6.32 μg de proteína. Los efectos tóxicos estuvieron relacionados con la dosis: los pavitos que recibieron un preparado que contenía 158 μg de proteína murieron en 4 a 6.5 horas, los que recibieron 31.6 y 6.32 μg de proteína murieron en 25 a 30 horas y los que recibieron 1.2 μg sobrevivieron los 6 días del estudio y aparentemente no fueron afectados. El examen histológico de los pavitos que recibieron dosis letales de toxina demostró la degeneración y necrosis de las células del parénquima hepático y pancreático, así como hiperemia, hemorragia y necrosis de la mucosa del intestino delgado. No se observaron lesiones en pavitos que recibieron dosis subletales de toxina o en pavitos no inoculados. La inoculación intranasal repetida de pavitos con bacterias sonicadas no produjo signos clínicos de enfermedad o lesiones macroscópicas. |
| URL: | http://www.jstor.org/stable/1590883 |
| Short Title: | Avian Diseases |
Taxonomic name: